Roles of zinc ( l 1 ) ion in zinc enzymes

نویسنده

  • Eiichi Kimura
چکیده

Zinc@) complexes of macrocyclic polyamines 1,2 and 3 make good models for zinc enzyme (e.g., carbonic anhydrase, alcohol dehydrogenase, phosphatase) active centers. Intrinsic acid properties of Zn** pertinent to the biological functions are disclosed. Zinc(II) ion is not only important kinetically but it also plays an indispensable role thermodynamically.

برای دانلود رایگان متن کامل این مقاله و بیش از 32 میلیون مقاله دیگر ابتدا ثبت نام کنید

ثبت نام

اگر عضو سایت هستید لطفا وارد حساب کاربری خود شوید

منابع مشابه

Changes in metabolic enzymes levels exposed to zinc and cadmium in the snow trout (Schizothorax zarudnyi)

Nowadays, the entrance of pollutants including heavy metals in environment threatens the life of aquatic animals. In this study, the effect of zinc chloride (6 mg/l) and cadmium chloride (5 mg/l) exposure were studied on the activity of some metabolic enzymes in the liver, gills, brain and muscle in Snow trout (Schizothorax zarudnyi). The results showed that zinc caused a significant increase i...

متن کامل

A variety of roles for versatile zinc in metallo-β-lactamases.

Metallo-β-lactamases are important as a major source of resistance of pathogenic bacteria to the widely used β-lactam antibiotics. They show considerable diversity in terms of sequence and are grouped into three subclasses, B1, B2 and B3, which share a common overall fold. In each case the active enzyme has binding sites for two zinc ions in close proximity, although the amino-acid residues whi...

متن کامل

P 134: Use of Zinc in Drugs to Improve Neuroinflammation Disease

Zinc is a substance that regulates neural excitability by binding whit sodium channel and potassium channel. The efficiency of free zinc ion, make down the neural survival rate, reduced the peak amplitude of Na+ and make depolarization Na channel, increased the peak amplitude of transition outward k+ currents and delayed rectifier. Also it is an effective blocker of one subtype of tetrodoxine (...

متن کامل

Effect of trinitroglycerin therapy on serum zinc and copper levels and liver enzyme activities in BALB/c mice infected with Leishmania major MRHO/IR/75/ER

Objective(s):To evaluate the effect of trinitroglycerin (TNG) as nitric oxide donor agent on serum copper (Cu) and zinc (Zn) levels and liver enzymes in BALB/c mice infected with Leishmania major (L. major) MRHO/IR/75/ER. Materials and Methods: Inbred female mice were divided into three groups: healthy group (uninfected naive mice), control group (infected with L. major), and test group (L. maj...

متن کامل

Evaluation the Effects of Sub-lethal concentrations of Zinc Chloride on hepatic enzymes activity in grey mullet (Mugil Cephalus) in vitro

In the recent years, water pollution by contaminations are increasing rapidly, the problems of aquatic pollution with heavy metals which is one of the important pollutions indicate that necessary to assess in fish as an important source of human food. The aim of this study was investigated the sub-lethal effects of zinc chloride on hepatic enzymes activity in grey mullet (Mugil Cephalus). In th...

متن کامل

ذخیره در منابع من


  با ذخیره ی این منبع در منابع من، دسترسی به آن را برای استفاده های بعدی آسان تر کنید

عنوان ژورنال:

دوره   شماره 

صفحات  -

تاریخ انتشار 2004